(6)おわりに

  • 脂質異常症の管理では脂質そのものの検査に加え,心血管疾患の家族歴や喫煙の有無・糖代謝・血圧・腎機能・体重とともに更年期症状についてもスクリーニングすることが重要である.
  • 女性の一生を診る産婦人科医として,薬剤による脂質代謝への影響を正しく理解することが重要である.

文献

  • 1)Ikenoue N, Wakatsuki A, Okatani Y. Small low-density lipoprotein particles in women with natural or surgically induced menopause. Obstet Gynecol. 93:566-570, 1999
  • 2)Nigon F, Lesnik P, Rouis M, et al. Discrete subspecies of human low density lipoproteins are heterogeneous in their interaction with the cellular LDL receptor. J Lipid Res. 32:1741-1753, 1991
  • 3)Annual report of Women’s Health Care Committee, Japan Society of Obstetrics and Gynecology, 2013. J Obstet Gynaecol Res. 40(2): 353-359, 2014
  • 4)Nakamura H, Arakawa K, Itakura H, et al: Primary prevention of cardiovascular disease in Japan: result of the Management of Elevated Cholesterol in the Primary Prevention Group of Adult Japanese(MEGA),randomised study with pravastatin. Lancet. 368: 1155-1163, 2006
  • 5)日本動脈硬化学会編.動脈硬化性疾患予防ガイドライン 2022 年版.日本動脈硬化学会,2022
  • 6)女性の動脈硬化性疾患発症予防のための管理指針 2017 年版.日本女性医学学会
  • 7)Nii S, Shinohara K, Matsushita H, et al. Hepatic Effects of Estrogen on Plasma Distribution of Small Dense Low-Density Lipoprotein and Free Radical Production in Postmenopausal Women. J Atheroscler Thromb. 23(7): 810-818. 2016
  • 8)Takahiro Sakurada, et al. Effects of androgenic properties of progestin combined with ethinyl estradiol on vascular endothelial reactivity, plasma lipids and free radical production in women with endometriosis. J Obstet Gynaecol Res. 47(3): 941-948, 2021. Epub 2021 Jan 6.